The four key preventive elements of fatigued driving (4P's of Fatigue) can be summarized as: Plan, Physical, Physical Environment, and Prompt. For planning, it is essential to scientifically schedule driving time and adhere to the "Golden 4-2-20 Rule", which stipulates no more than 4 hours of continuous daytime driving or 2 hours at night, with at least 20 minutes of rest after each segment. Physical management involves securing 7-8 hours of quality sleep daily, avoiding sleep deprivation, periodically adjusting seating positions and stretching limbs during drives, opting for easily digestible vitamin-rich meals, and abstaining from alcohol or high-sugar diets. Environmental control entails maintaining cabin temperature at approximately 22℃, ventilating hourly by opening windows, and using breathable seat covers to minimize discomfort. Vigilance maintenance focuses on promptly recognizing fatigue indicators (e.g., lapses in concentration, frequent blinking), countering them with measures like invigorating mint wipes, consuming unsweetened coffee, or taking short breaks for stretching, while refraining from driving after ingesting sedating medications. Implementing these measures holistically is crucial for ensuring road safety.